The effect of particle agglomeration on the formation of a surface-connected compartment induced by hydroxyapatite nanoparticles in human monocyte-derived macrophages☆

@inproceedings{Mller2014TheEO,
  title={The effect of particle agglomeration on the formation of a surface-connected compartment induced by hydroxyapatite nanoparticles in human monocyte-derived macrophages☆},
  author={Karin H. M{\"u}ller and Michael Motskin and Alistair J. Philpott and Alexander F. Routh and Catherine M Shanahan and Melinda J Duer and Jeremy N. Skepper},
  booktitle={Biomaterials},
  year={2014}
}
Agglomeration dramatically affects many aspects of nanoparticle-cell interactions. Here we show that hydroxyapatite nanoparticles formed large agglomerates in biological medium resulting in extensive particle uptake and dose-dependent cytotoxicity in human macrophages. Particle citration and/or the addition of the dispersant Darvan 7 dramatically reduced mean agglomerate sizes, the amount of particle uptake and concomitantly cytotoxicity. More surprisingly, agglomeration governed the mode of… CONTINUE READING
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