The effect of pain on cognitive function: A review of clinical and preclinical research

  title={The effect of pain on cognitive function: A review of clinical and preclinical research},
  author={Orla Moriarty and Brian E. McGuire and David P. Finn},
  journal={Progress in Neurobiology},

The Effect of Pain on Cognitive Function: Preclinical and Clinical Investigations

The studies provide some evidence for deficits in cognitive performance associated with the SNL model of neuropathic pain, which were dependent on age and on the cognitive task, which may contribute to the observed impairments in cognitive behaviour.

Cognitive Impairment in Patients with Chronic Neuropathic or Radicular Pain: An Interaction of Pain and Age

This study supports and extends previous research indicating that chronic pain is associated with impaired memory and attention and specifically investigated the interaction effect of pain and age on cognitive performance.

Cognition and pain

  • O. MoriartyD. Finn
  • Biology, Psychology
    Current opinion in supportive and palliative care
  • 2014
Progress has been made in understanding the complex relationship between pain and cognitive function, however, both synthesis of current research findings and further novel research studies are required to maximize the therapeutic potential.

Cognition and Pain: A Review

This narrative review explores the available evidence that has investigated cognitive changes associated with pain and the anatomical, biochemical, and molecular association of pain and neuro-cognition and focuses on the cognitive impairment caused by analgesic medications.

Optimizing Cognitive Function in Persons With Chronic Pain

There are several options for remediation, including compensatory, restorative, and neuromodulatory approaches to directly modify cognitive functioning, as well as physical, psychological, and medication optimization methods to target secondary factors that may interfere with cognition.

Chronic pain and cognitive function

2 . 3 Pain Within the Extremities

Investigating the mechanism of inflammatory sickness behaviors in MS could lead to a better understanding of the links between pain and cognition, and allow better management of both symptoms.

Experimental pain processing in individuals with cognitive impairment: current state of the science

Overall, the existing data suggest that pain processing is altered in most individuals with CI compared with cognitively intact matched controls, and altered experimental pain processing in CI will facilitate the development of improved diagnostic and therapeutic approaches for pain in individuals withCI.

Chronic Pain and Cognition

Patients with chronic pain appear to have worse cognitive functioning than do healthy controls, particularly in the areas of attention, processing speed, and executive functioning, and the duration and intensity of chronic pain appears to be negatively correlated with cognitive function.



Cognitive Impairment in Musculoskeletal Pain Patients

The need for further research to understand the relationship of poor performance on cognitive tasks to the etiology, maintenance and rehabilitation of pain problems is suggested.

Cognitive impairment in patients with chronic pain: The significance of stress

The role of emotional distress and other aspects of suffering in the cognitive impairment that often is apparent in patients with chronic pain is examined.

Relationship between Chronic Pain and Cognition in Cognitively Intact Older Persons and in Patients with Alzheimer’s Disease

The results show that significant correlations between specific cognitive functions, pain intensity and pain affect were lacking in the cognitively intact older persons, and Cognition, in particular memory, appeared to be related to depressive symptoms.

Chronic Pain and Neuropsychological Functioning

Despite suggestive findings, further studies are needed to clarify the variables that mediate the impact of pain on neuropsychological functioning and the unique role of various symptoms often associated with chronic pain.

The impact of neuropathic pain on health-related quality of life

The results provide strong evidence that the presence and severity of neuropathic pain are associated with greater impairments in a number of important HRQoL domains and suggest that a biopsychosocial approach would be appropriate for understanding and treating neuropathicPain.

Forebrain pain mechanisms

Predicting complaints of impaired cognitive functioning in patients with chronic pain.

The relationship between pain and mental flexibility in older adult pain clinic patients.

In community dwelling older adults, neither pain nor mood was associated with measures of short-term memory or information-processing speed, however, pain severity wasassociated with decreased performance on a test of number-letter switching, indicating a relationship between pain and mental flexibility.

Neuropsychological impairment in fibromyalgia: relation to depression, fatigue, and pain.

  • J. Suhr
  • Psychology, Medicine
    Journal of psychosomatic research
  • 2003