• Medicine
  • Published in Cancer research 1966

The effect of pH upon the antitumor activity and toxicity of nitrogen mustard.

@article{Cutts1966TheEO,
  title={The effect of pH upon the antitumor activity and toxicity of nitrogen mustard.},
  author={James H. Cutts and Ian G. Walker},
  journal={Cancer research},
  year={1966},
  volume={26 7},
  pages={
          1386-9
        }
}
Mice were given single injections of HN2 solution at pH 8 or pH 2. The alkaline preparation had an LD50 of about 2 mg/kg while that for the acidic preparation was about 5 mg/kg. A similar difference in toxicity was seen when the HN2 was given as a series of small daily doses. The greater toxicity of the alkaline preparation was manifest also in the hematologic findings, and in the earlier deaths of mice given this preparation. Using animals bearing either the L-1210 ascites tumor or the Ehrlich… CONTINUE READING