The effect of pH on the alternative oxidase activity in isolated Acanthamoeba castellanii mitochondria.

@article{Jarmuszkiewicz2002TheEO,
  title={The effect of pH on the alternative oxidase activity in isolated Acanthamoeba castellanii mitochondria.},
  author={Wiesława Jarmuszkiewicz and Lilla Hryniewiecka and Francis E. Sluse},
  journal={Journal of bioenergetics and biomembranes},
  year={2002},
  volume={34 3},
  pages={221-6}
}
Mitochondria of Acanthamoeba castellanii possess a cyanide-resistant GMP-stimulated ubiquinol alternative oxidase in addition to the cytochrome pathway. In a previous work it has been observed that an interaction between the two ubiquinol-oxidizing pathways exists in intact A. castellanii mitochondria and that this interaction may be due to a high sensitivity of the alternative oxidase to matrix pH. In this study we have shown that the alternative oxidase activity reveals a pH-dependence with a… CONTINUE READING