The effect of p-aminosalicyclic acid on iron transport and assimilation in mycobacteria.

@article{Brown1975TheEO,
  title={The effect of p-aminosalicyclic acid on iron transport and assimilation in mycobacteria.},
  author={Katherine A. Brown and Colin Ratledge},
  journal={Biochimica et biophysica acta},
  year={1975},
  volume={385 2},
  pages={207-20}
}
p-Aminosalicylic acid inhibits growth of Mycobacterium bovis BCG and Mycobacterium smegmatis more effectively if cells are growing with a sufficiency of iron (more than 1 mu g Fe/ml) in the medium than if cells are deficient in iron (smaller than 0.1 mu g Fe/ml). In iron-deficient cultures formation of mycobactin, an ionophore for iron transport, is strongly inhibited by p-aminosalicylic acid. Uptake of iron into cell suspensions is also inhibited and the activity of several iron-containing… CONTINUE READING

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