The effect of oxytocin on cell proliferation in the human prostate is modulated by gonadal steroids: implications for benign prostatic hyperplasia and carcinoma of the prostate.

@article{Whittington2007TheEO,
  title={The effect of oxytocin on cell proliferation in the human prostate is modulated by gonadal steroids: implications for benign prostatic hyperplasia and carcinoma of the prostate.},
  author={Kate Whittington and Belinda Connors and Keith J King and Steve Assinder and Karole Hogarth and Helen Nicholson},
  journal={The Prostate},
  year={2007},
  volume={67 10},
  pages={1132-42}
}
BACKGROUND Oxytocin (OT) is implicated in regulating prostate growth. OT concentrations are increased in benign, and decreased in malignant prostate disease. This study investigated whether the altered concentrations of OT present in prostate disease affect the proliferation of malignant and non-malignant human prostate cells. METHODS The effects of varying concentrations of OT and gonadal steroids on cell proliferation of non-malignant prostatic epithelial (PrEC) and stromal (PrSC) cells and… CONTINUE READING