The effect of oxidative stress on nucleotide-excision repair in colon tissue of newborn piglets.

@article{Langie2010TheEO,
  title={The effect of oxidative stress on nucleotide-excision repair in colon tissue of newborn piglets.},
  author={Sabine A. S. Langie and Pawel Kowalczyk and Barbara Tudek and Romuald Zabielski and Tomasz Dziaman and Ryszard Olinski and Frederik-Jan van Schooten and Roger W L Godschalk},
  journal={Mutation research},
  year={2010},
  volume={695 1-2},
  pages={75-80}
}
Nucleotide-excision repair (NER) is important for the maintenance of genomic integrity and to prevent the onset of carcinogenesis. Oxidative stress was previously found to inhibit NER in vitro, and dietary antioxidants could thus protect DNA not only by reducing levels of oxidative DNA damage, but also by protecting NER against oxidative stress-induced inhibition. To obtain further insight in the relation between oxidative stress and NER activity in vivo, oxidative stress was induced in newborn… CONTINUE READING

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