The effect of oxidative stress on Ca2+ release and capacitative Ca2+ entry in vascular endothelial cells.

@article{Florea2008TheEO,
  title={The effect of oxidative stress on Ca2+ release and capacitative Ca2+ entry in vascular endothelial cells.},
  author={Stela M. Florea and Lothar A Blatter},
  journal={Cell calcium},
  year={2008},
  volume={43 4},
  pages={
          405-15
        }
}
Oxidative stress imposed by the accumulation of oxygen free radicals (reactive oxygen species, ROS) has profound effects on Ca2+ homeostasis in the vascular endothelium, leading to endothelial dysfunctions and the development of cardiovascular pathologies. We tested the effect of the oxidant and ROS generator tert-butyl-hydroperoxide (tBuOOH) on Ca2+ signaling in single cultured calf pulmonary artery endothelial (CPAE) cells loaded with the fluorescent Ca2+ indicator indo-1. Acute brief (5 min… CONTINUE READING
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