The effect of ovariectomy and estradiol on rabbit bladder smooth muscle contraction and morphology.

@article{Aikawa2003TheEO,
  title={The effect of ovariectomy and estradiol on rabbit bladder smooth muscle contraction and morphology.},
  author={Ken Aikawa and Takashi Sugino and Seiji Matsumoto and Paul Chichester and Catherine Whitbeck and Robert M. Levin},
  journal={The Journal of urology},
  year={2003},
  volume={170 2 Pt 1},
  pages={634-7}
}
PURPOSE The bladder can be considered a target organ for the actions of estrogen. Decreases in circulating estrogen after menopause have been associated with bladder dysfunctions, including incontinence and detrusor instability. We determined the effects of estrogen on rabbit bladder contractile function and morphology. MATERIALS AND METHODS Female New Zealand White rabbits were ovariectomized or sham operated and treated with vehicle or estradiol (1 mg/kg weekly) for 5 weeks. Serum estradiol… CONTINUE READING

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