The effect of osteoimmunomodulation on the osteogenic effects of cobalt incorporated β-tricalcium phosphate.

@article{Chen2015TheEO,
  title={The effect of osteoimmunomodulation on the osteogenic effects of cobalt incorporated β-tricalcium phosphate.},
  author={Zetao Chen and Jones Yuen and Ross Crawford and Jiang Chang and Chengtie Wu and Yin Xiao},
  journal={Biomaterials},
  year={2015},
  volume={61},
  pages={126-38}
}
Osteoblast lineage cells are direct effectors of osteogenesis and are, therefore, commonly used to evaluate the in vitro osteogenic capacity of bone substitute materials. This method has served its purposes when testing novel bone biomaterials; however, inconsistent results between in vitro and in vivo studies suggest the mechanisms that govern a material's capacity to mediate osteogenesis are not well understood. The emerging field of osteoimmunology and immunomodulation has informed a… CONTINUE READING