The effect of osteogenic protein-1 in instrumented and noninstrumented posterolateral fusion in rabbits.


BACKGROUND CONTEXT The use of rigid instrumentation combined with bone graft makes intuitive sense given the requirements for vascular ingrowth, bone formation and a stable environment for the cellular events of healing to develop. However, with the advances of potent osteoinductive growth factors, the role of internal fixation may come into question… (More)