The effect of osmotic stress on the production of nukacin ISK-1 from Staphylococcus warneri ISK-1

@article{Sashihara2001TheEO,
  title={The effect of osmotic stress on the production of nukacin ISK-1 from Staphylococcus warneri ISK-1},
  author={Toshihiro Sashihara and Meixia Dan and Hirokazu Kimura and Hiromi Matsusaki and Kenji Sonomoto and Ayaaki Ishizaki},
  journal={Applied Microbiology and Biotechnology},
  year={2001},
  volume={56},
  pages={496-501}
}
The effects of several additives on the production of a lantibiotic, nukacin ISK-1, from Staphylococcus warneri ISK-1, in batch fermentation were studied. NaCl, KCl and sorbitol stimulated nukacin ISK-1 production. The addition of 1.4 M NaCl increased nukacin ISK-1 activity 1.5-fold over the control, while cell growth and glucose consumption were inhibited. Nukacin ISK-1 production increased with increasing osmolarity of the medium up to about 3 osmol/kg; however, further increases in… CONTINUE READING
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