The effect of olanzapine pretreatment on acute cocaine toxicity in mice

  title={The effect of olanzapine pretreatment on acute cocaine toxicity in mice},
  author={Kennon Heard and Nathan R Cleveland and Shay Krier},
  journal={Clinical Toxicology},
  pages={542 - 544}
Background. Acute cocaine poisoning causes neuroexcitation and can be fatal. The toxic effects of cocaine can be attenuated by antagonists of serotonin, muscarinic cholinergic, and dopamine receptors. Olanzapine, an atypical antipsychotic medication, is an antagonist of these receptors. The objective of this study is to evaluate the efficacy of olanzapine pretreatment for attenuation of acute cocaine toxicity using a mouse model. Methods. Eighty male CF-1 mice were randomly assigned to… 

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    The Journal of pharmacology and experimental therapeutics
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