The effect of nucleotides and adenosine on stimulus-evoked glutamate release from rat brain cortical slices.

@article{Bennett2000TheEO,
  title={The effect of nucleotides and adenosine on stimulus-evoked glutamate release from rat brain cortical slices.},
  author={Gillian C Bennett and Michael R. Boarder},
  journal={British journal of pharmacology},
  year={2000},
  volume={131 3},
  pages={617-23}
}
Evidence has previously been presented that P1 receptors for adenosine, and P2 receptors for nucleotides such as ATP, regulate stimulus-evoked release of biogenic amines from nerve terminals in the brain. Here we investigated whether adenosine and nucleotides exert presynaptic control over depolarisation-elicited glutamate release. Slices of rat brain cortex were perfused and stimulated with pulses of 46 mM K(+) in the presence of the glutamate uptake inhibitor L-trans-pyrrolidine-2,4… CONTINUE READING