The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.

Abstract

Protozoan parasites from the Plasmodiidae family are the causative agents of malaria. Inhibition of hypoxanthine-guanine-(xanthine) phosphoribosyltransferase (HG(X)PRT) has been suggested as a target for development of new anti-malarial therapeutics. Acyclic nucleoside phosphonates (ANPs) are potent and selective inhibitors of plasmodial HG(X)PRTs. A new… (More)
DOI: 10.1016/j.ejmech.2013.06.032

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Cite this paper

@article{Baszczyski2013TheEO, title={The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.}, author={Ondřej Baszczyňski and Dana Hockov{\'a} and Zlatko Janeba and Anton{\'i}n Hol{\'y} and Petr Jansa and Martin Dra{\vc}{\'i}nsk{\'y} and Dianne T. Keough and Luke W. Guddat}, journal={European journal of medicinal chemistry}, year={2013}, volume={67}, pages={81-9} }