The effect of nicotine on aortic endothelial cell turnover. An autoradiographic study.

@article{Zimmerman1985TheEO,
  title={The effect of nicotine on aortic endothelial cell turnover. An autoradiographic study.},
  author={Mathew Zimmerman and John Mcgeachie},
  journal={Atherosclerosis},
  year={1985},
  volume={58 1-3},
  pages={
          39-47
        }
}
Endothelial injury and increased mitotic activity are early features in the pathogenesis of intimal thickening in arteries. This study examines the effect of systemic nicotine on mitotic activity in endothelial cells. Nine adult mice were given nicotine in their drinking water for 5 weeks. The dose (5 mg/kg body wt/day) was equivalent to a human smoking 50-100 cigarettes/day. A group of 8 similar mice, not exposed to nicotine, was the control. At the end of the exposure period all mice were… CONTINUE READING

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