The effect of niaprazine on the turnover of 5-hydroxytryptamine in the rat brain

@article{Keane1982TheEO,
  title={The effect of niaprazine on the turnover of 5-hydroxytryptamine in the rat brain},
  author={Peter E. Keane and Margherita Strolin Benedetti and James Dow},
  journal={Neuropharmacology},
  year={1982},
  volume={21},
  pages={163-169}
}
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18 Citations
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18 Citations

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Molecular pharmacology of niaprazine
Mass spectrometric studies of the metabolites of niaprazine
Identification and quantitation of 1-arylpiperazines, metabolites resulting from side-chain cleavage of (4-substituted aryl-1-piperazinyl)alkyl heterocyclic derivatives in rat plasma and brain.
1-Benzylpiperazine and other Piperazine-based Derivatives
The effect of niaprazine on some common sleep disorders in children
TLDR
It is concluded that niaprazine seems to reprensent an effective and safe drug for the therapy of frequent nighttime waking and inability to fall asleep.
Metabolic interactions with piperazine-based 'party pill' drugs.
TLDR
Whether predictions can be made about global interactions between 'party pills' constituents and other drugs metabolised by the same cytochrome P450 (CYP) isoenzymes is investigated.
Treatment of alternating hemiplegia of childhood with aripiprazole
TLDR
Modulation of both dopamine and histamine systems together appears to be important in the treatment of AHC and further investigation of such pharmacotherapies is suggested.
Designer Drug (DD) abuse in Poland; a review of the psychoactive and toxic properties of substances found from seizures of illegal drug products and the legal consequences thereof. Part II--piperazines/piperidines, phenylethylamines, tryptamines and miscellaneous 'others'.
TLDR
These two articles may help suitable legislation to be rapidly devised to make the prohibition of DDs permanent whenever deemed necessary, as well as providing an up-to-date reference source for those engaged in the DD issue.
Metabolic interactions with piperazine‐based ‘party pill’ drugs
TLDR
This study aimed to determine whether predictions can be made about global interactions between ‘party pills’ constituents and other drugs metabolised by the same cytochrome P450 (CYP) isoenzymes.
Errata
TLDR
A successful trial of amantadine hydrochloride for two patients with alternating hemiplegia of childhood and the effect of niaprazine on the turnover of 5-hydroxytryptamine in the rat brain.
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TLDR
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TLDR
This study has compared the action of CPP with that of quipazine in respect of their influence on the in vivo activities of tyrosine and tryptophan hydroxylases in male Wistar rats and found that CPP induced a behavioural syndrome characteristic for central 5-HTergic stimulation.
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