The effect of niaprazine on the turnover of 5-hydroxytryptamine in the rat brain

@article{Keane1982TheEO,
  title={The effect of niaprazine on the turnover of 5-hydroxytryptamine in the rat brain},
  author={Peter E. Keane and Margherita Strolin Benedetti and James Dow},
  journal={Neuropharmacology},
  year={1982},
  volume={21},
  pages={163-169}
}
Molecular pharmacology of niaprazine
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Errata
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A successful trial of amantadine hydrochloride for two patients with alternating hemiplegia of childhood and the effect of niaprazine on the turnover of 5-hydroxytryptamine in the rat brain.
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Niaprazine, a selective brain catecholamine depletor
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TLDR
The data support the conclusion that brain 5-HT synthesis was accelerated in rats with lowered brain NE and Brain 5-HIAA concentrations were markedly increased concurrent with the inhibition of dopamine β-hydroxylase and depletion of NE stores.
THE EFFECT OF PRENYLAMINE ON THE METABOLISM OF CATECHOL AMINES AND 5-HYDROXYTRYPTAMINE IN BRAIN AND ADRENAL MEDULLA.
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TLDR
It was shown in 1962 that adrenal medullary granules lose their catechol amines in the presence of 10-4 M-prenylamine and smaller concentrations prevented the uptake of amines and decreased their spontaneous release into the medium.
5‐Hydroxytryptamine‐like properties of m‐chlorophenylpiperazine: comparison with quipazine
TLDR
This study has compared the action of CPP with that of quipazine in respect of their influence on the in vivo activities of tyrosine and tryptophan hydroxylases in male Wistar rats and found that CPP induced a behavioural syndrome characteristic for central 5-HTergic stimulation.
Specificity of a rat behavioral model for serotonin receptor activation.
TLDR
The results suggest that systemic levodopa or intraventricular dopamine produces the behavioral signs through 5-HT mechanisms; endogenous catecholamine mechanisms are not involved directly in either the cause or expression of the behavioral syndrome.
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