The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer

  title={The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer},
  author={Tomohiro Hakozaki and Ljiljana Minwalla and Jack Zhuang and Mark Chhoa and Akira Matsubara and Kukizo Miyamoto and Amanda Greatens and G G Hillebrand and D. L. Bissett and Raymond E. Boissy},
  journal={British Journal of Dermatology},
Summary Background Cutaneous hyperpigmentation occurs in multiple conditions. In addition, many Asian women desire a lighter skin colour. Thus, there is a need for the development of skin lightening agents. Niacinamide is a possible candidate. 

Survey and mechanism of skin depigmenting and lightening agents

The type and amount of melanin synthesized by the melanocyte, and its distribution pattern in the surrounding keratinocytes, determines the actual color of the skin. Melanin forms through a series of

Use of nicotinamide in dermatology

The evidence underlying the use of nicotinamide for various dermatological indications, including nonmelanoma cancer prophylaxis, blistering disorders, acne vulgaris and cosmetic indications, is reviewed, and its future role in dermatological practice is speculated upon.

Efficacy of a Topical Agent Containing Tranexamic Acid, Niacinamide and Kojic Acid in Melasma

It is necessary to select patients suitable for vaginal or laparoscopic mesh placement for Melasma preoperatively on the basis of prior history and once they provide informed consent for surgery.

Reduction in facial hyperpigmentation after treatment with a combination of topical niacinamide and tranexamic acid: a randomized, double‐blind, vehicle‐controlled trial

  • Do Hyun LeeI. Y. Oh Yoo Mi Choi
  • Medicine
    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging
  • 2014
There is a need for the development of skin lightening agents, and niacinamide and tranexamic acid (TXA) are promising candidates.

Topical treatment of hyperpigmentation disorders.

Skin‐lightening effects of a new face care product in patients with melasma

This study highlights the need to understand more fully the role that environmental factors, particularly sunlight exposure, play in the development of Melasma.

Effects of vitamin C vs. multivitamin on melanogenesis: comparative study in vitro and in vivo

This work has shown that high levels of vitamin C in the blood of mice treated with a single multivitamin can have an anti-inflammatory effect on mice with hyperpigmented bodies.

The combination of sucrose dilaurate and sucrose laurate suppresses HMGB1: an enhancer of melanocyte dendricity and melanosome transfer to keratinocytes

Hyperpigmented spots are common issues in all ethnicities, involving multiple intrinsic and extrinsic factors such as UVB exposure, hormone balance, inflammatory status and ageing.

Effect of tranexamic acid on melasma: a clinical trial with histological evaluation

Tranexamic acid (TXA), a plasmin inhibitor, is reported to improve melasma when injected locally and the effects of oral and topical TXA on melasma have not been well studied and the underlying mechanism remains unclear.

Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N‐acetyl glucosamine: results of a randomized, double‐blind, vehicle‐controlled trial

Topical niacinamide and N‐acetyl glucosamine each individually inhibit epidermal pigmentation in cell culture to reduce the appearance of hyperpigmentation.



Constitutive skin tone and sunscreen effects : UV-induced skin darkening in negroid skin

We planned and implemented two studies to establish: (1) whether any relationship existed between constitutive skin tone and sun-induced skin darkening in Negroid subjects, and (2) whether sunscreen

Topical tretinoin (retinoic acid) treatment for liver spots associated with photodamage.

Topical 0.1 percent tretinoin significantly improves both clinical and microscopical manifestations of liver spots; these lesions do not return for at least six months after therapy is discontinued.

Prevention of photoimmunosuppression and photocarcinogenesis by topical nicotinamide.

  • H. Gensler
  • Medicine, Biology
    Nutrition and cancer
  • 1997
Topical nicotinamide prevented the immunosuppression and skin tumor induction by UVB irradiation in UV-irradiated mice.

The cytotoxicity and apoptosis induced by 4-tertiary butylphenol in human melanocytes are independent of tyrosinase activity.

Data suggest that 4-tertiary butylphenol cytotoxicity is not mediated via tyrosinase, and suggests that cutaneous depigmentation induced by phenolic derivatives results from the loss of functional melanocytes by an apoptotic process.

Inhibition of melanosome transfer results in skin lightening.

It is shown that modulation of protease-activated receptor 2 activation affects melanosome transfer into keratinocytes, resulting in changes in pigment production and deposition, and the use of RWJ-50353 to modulate prote enzyme-activated receptors 2 activation could lead to a new class of depigmenting agents.

Use of human skin reconstructs in the study of pigment modifiers.

The effect of pigment modifiers was demonstrated ex vivo as expected from in vivo data on skin color, numbers of melanocytes, melanosome transfer, and melanin content.

The protease-activated receptor 2 regulates pigmentation via keratinocyte-melanocyte interactions.

Evidence is provided that the protease-activated receptor 2 (PAR-2) expressed on keratinocytes, but not on melanocytes, is involved in melanosome transfer and therefore may regulate pigmentation.

Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier

Nicotinamide improved the permeability barrier by stimulating de novo synthesis of ceramides, with upregulation of serine palmitoyltransferase (SPT) and other intercellular lipids.

Endothelin-1 as a new melanogen: coordinated expression of its gene and the tyrosinase gene in UVB-exposed human epidermis.

The findings suggest that ET-1 is an important mediator for UVB-induced pigmentation in the epidermis in vivo.

Keratinocytes play a role in regulating distribution patterns of recipient melanosomes in vitro.

The results suggest that regulatory factor(s) within the keratinocyte determine recipient melanosome distribution patterns, and that recipients melanosomes, regardless of origin, are predominantly distributed individually by keratinocytes from dark skin, and in membrane-bound clusters by those from light skin.