The effect of nebivolol on asymmetric dimethylarginine system in spontaneously hypertension rats.

  title={The effect of nebivolol on asymmetric dimethylarginine system in spontaneously hypertension rats.},
  author={Yan Wang and M. Zhang and Y. Liu and M. Chen},
  journal={Vascular pharmacology},
  volume={54 1-2},
  • Yan Wang, M. Zhang, +2 authors M. Chen
  • Published 2011
  • Chemistry, Medicine
  • Vascular pharmacology
  • Asymmetric dimethylarginine (ADMA) is an endogenous and competitive inhibitor of nitric oxide synthase. Plasma level of ADMA is elevated in patients with hypertension. In these patients, plasma ADMA levels are correlated with the severity of endothelial dysfunction. Nebivolol, a highly selective blocker of beta1-adrenergic receptors, is the only beta-blocker known to induce vascular production of NO. There is little data on the effect of nebivolol on ADMA system in spontaneously hypertensive… CONTINUE READING
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