The effect of narcotics and narcotic antagonists on the tail‐flick response in spinal mice

  title={The effect of narcotics and narcotic antagonists on the tail‐flick response in spinal mice},
  author={William L. Dewey and James W. Synder and Louis S. Harris and John F. Howes},
  journal={Journal of Pharmacy and Pharmacology},
Irwin, Houde & others (1951) reported that the tail-flick response of rats to radiant heat has the characters of a simple reflex. The ability of spinal rats to respond to this stimulus has been confirmed and extended (Winter & Flataker, 1951 ; Bonnycastle, Cook & Ipsen, 1953). Morphine inhibited the reflex in spinal rats but a quantitative difference observed between its effect in spinal rats and intact animals indicated that a second action might exist in its capacity to increase supraspinal… 

Activity of major analgesics on motor nociceptive responses in decerebrate mice

Three major analgesics were tested on intact and decerebrate mice for their ability to prolong the reaction time of motor nociceptive responses in two established analgesimetric tests: the thermal receptacle and the hot-plate method.

Narcotic-antagonist analgesics: interactions with cholinergic systems.

A high correlation has been found between the activity of these compounds in this test procedure and their potency as analgesics in man and the hypothesis that cholinergic systems may be involved in the analgesic action of these drugs.

Antinociceptive effect of intrathecal morphine in tolerant and nontolerant spinal rats

Analgesic mechanism of neurotropin: relation to the serotonergic system and influence of spinal cord transection.

  • E. ItohT. Hata
  • Biology, Psychology
    Japanese journal of pharmacology
  • 1989
The data suggest that neurotropin does not directly act on pain transmitters at the spinal cord level, but acts at the supraspinal level, resulting in an inhibition of pain transmitter release atThe spinal level by mediating pain inhibitory systems such as the serotonergic system in addition to the noradrenergic and GABAergic systems previously reported.

Baclofen is antinociceptive in the spinal intrathecal space of animals.




The effects of morphine methadone and meperidine on some reflex responses of spinal animals to nociceptive stimulation.

A method was suggested whereby predetermination of this physical limitation of the D9Amour-Smith technique may be utilized to define a uniform "maximal measurable effect" ceiling for any given intensity of stimulus used.

The effect of cortisone, desoxycorticosterone, and adrenocorticotrophic hormone upon the responses of animals to analgesic drugs.

  • C. WinterL. Flataker
  • Biology, Medicine
    The Journal of pharmacology and experimental therapeutics
  • 1951
Cortisone proved to have a synergistic action with the analgesic antagonist, N-allylnormorphine, and provided partial protection in mice against toxic doses of methadone and reduced the effect of morphine on the spinal reflex, while DCA enhanced it.

Counteraction of Narcotic Antagonist Analgesics by the Narcotic Antagonist Naloxone

  • H. BlumbergH. B. DaytonP. Wolf
  • Biology, Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1966
Naloxone completely antagonized the potent analgesic activity of pentazocine, nalorphine, cyclazocines, and cy-clorphan, and also antagonizes the weak analgesicactivity of levallorphan.

The Physiology ofSynapses

  • 1964

Pharmacologist , 10 , 189

  • 1953

Acfu pharmac

  • tox., 9, 332-336.
  • 1953