The effect of mouse spinal cord transection on the antinociceptive response to the gamma-aminobutyric acid agonists THIP (4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridine-3-ol) and baclofen.


The antinociceptive responses to the gamma-aminobutyric acid receptor agonists THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-3-ol) and baclofen were examined in spinally transected mice to define the central nervous system site of action for these drugs. Nociception was assessed using a tail-immersion assay. The results indicated that spinal transection… (More)


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