The effect of molecules in mother-of-pearl on the decrease in bone resorption through the inhibition of osteoclast cathepsin K.

@article{Duplat2007TheEO,
  title={The effect of molecules in mother-of-pearl on the decrease in bone resorption through the inhibition of osteoclast cathepsin K.},
  author={Denis Duplat and Marl{\`e}ne Gallet and Sophie Berland and Arul Marie and Lionel Dubost and Marthe Rousseau and Sa{\"i}d Kamel and Christian Milet and Michel Brazier and Evelyne Lopez and Laurent B{\'e}douet},
  journal={Biomaterials},
  year={2007},
  volume={28 32},
  pages={4769-78}
}
This study evaluates the effect of the mother-of-pearl (nacre) organic matrix on mammalian osteoclast activity and on cathepsin K protease. Rabbit osteoclasts were cultured on bovine cortical bone slices in the presence of water-soluble molecules extracted from nacre of the pearl oyster Pinctada margaritifera. Osteoclast resorption activity was determined by quantification of the resorption surface area on bovine bone slices. Papain and cathepsin K, B and L inhibition tests were performed in… CONTINUE READING

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