The effect of molecular adsorbent recirculating system on pathophysiological parameters in patients with acute liver failure

@article{Lai2005TheEO,
  title={The effect of molecular adsorbent recirculating system on pathophysiological parameters in patients with acute liver failure},
  author={Wai Kwan Lai and Geoffrey H. Haydon and David J. Mutimer and Nick Murphy},
  journal={Intensive Care Medicine},
  year={2005},
  volume={31},
  pages={1544-1549}
}
ObjectiveTo investigate the effect of the molecular adsorbent recirculating system (MARS) on physiological variables in patients with acute liver failure.DesignA prospective, observational study of MARS in addition to standard medical therapy in the management of patients presenting with acute liver failure.SettingA regional liver transplant centre.PatientsTen consecutive patients admitted with acute liver failure with a grade III or IV hepatic encephalopathy.InterventionsMARS therapy for 8 h… 
Molecular adsorbent recirculating system dialysis in patients with acute liver failure who are assessed for liver transplantation
TLDR
A statistically significant improvement of liver function was observed after MARS therapy, andTransplant-free recovery was more frequent than expected and the apparent benefit of MARS dialysis to treat acute liver failure needs to be confirmed by a controlled study.
Use of the molecular adsorbent recirculating system (MARS™) for the management of acute poisoning with or without liver failure
TLDR
Despite the lack of large multicentre randomized trials on the use of MARS™ in patients with acute liver failure, the literature shows clinical and biological benefit from this technique, and it is potentially a promising treatment for Patients with acute poisoning from drugs that have high protein-binding capacity and are metabolized by the liver.
Effect of Prometheus liver assist system on systemic hemodynamics in patients with cirrhosis: a randomized controlled study.
TLDR
Extra-corporal liver support with Prometheus is proven to be safe in patients with endstage liver disease but does not exert the beneficial effects on arterial pressure as seen in the MARS group.
Albumin Dialysis in Liver Failure: Comparison of Molecular Adsorbent Recirculating System and Single Pass Albumin Dialysis—A Retrospective Analysis
TLDR
This retrospective analysis suggests equal efficacy of MARS and SPAD; however, prospective assessment to further define the role of SPAD in the treatment of acute or acute‐on‐chronic liver failure is needed.
Utilisation de la dialyse MARS en toxicologie MARS albumin dialysis in toxicology
There is a growing interest of both bioartificial and non bioartificial devices to provide a support in patients with liver failure. Albumin dialysis with the Molecular Adsorbent Recirculating System
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TLDR
In clinical practice, MARS technique should be used in experienced centers for severe liver failure, particularly those from toxic origin, and more rarely for life-threatening poisonings with albumin-bound drugs, particularly when cardiovascular failure occurs.
Comparison of albumin dialysis devices molecular adsorbent recirculating system and ADVanced Organ Support system in critically ill patients with liver failure—A retrospective analysis
TLDR
In cycles with similar treatment times, both systems provided comparable reduction rates for bilirubin, renal replacement, coagulation, and metabolic parameters, and Citrate was the preferred anticoagulant in case of bleeding.
Albumin Dialysis With a Noncell Artificial Liver Support Device in Patients With Acute Liver Failure
TLDR
This randomized trial of MARS in patients with ALF was unable to provide definitive efficacy or safety conclusions because many patients had transplantation before administration of the intervention.
Addition of Molecular Adsorbent Recirculating System (MARS®) Albumin Dialysis for the Preoperative Management of Jaundiced Patients with Hilar Cholangiocarcinoma
TLDR
When combined with PBD, MARS dialysis appears to accelerate the decrease in SBL and thus may enable earlier surgery, and this hypothesis must be validated in a larger study.
MARS in the Treatment of Liver Failure: Controversies and Evidence
  • A. Chiu, S. Fan
  • Medicine
    The International journal of artificial organs
  • 2006
TLDR
Molecular Adsorbent Recirculation System is a form of extracorporeal detoxification system used as an artificial liver support system and in general a safe procedure, but there are still potential complications that need to be cautioned, along with various operative issues that are worth attention.
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