The effect of modulation of glutathione cellular content on busulphan-induced cytotoxicity on hematopoietic cells in vitro and in vivo

@article{Hassan2002TheEO,
  title={The effect of modulation of glutathione cellular content on busulphan-induced cytotoxicity on hematopoietic cells in vitro and in vivo},
  author={Z. Hassan and E. Hellstr{\"o}m-Lindberg and S. Alsadi and M. Edgren and H. H{\"a}gglund and M. Hassan},
  journal={Bone Marrow Transplantation},
  year={2002},
  volume={30},
  pages={141-147}
}
Busulphan is used in conditioning regimens prior to SCT. A relationship between exposure to busulphan, expressed as an area under the plasma concentration time curve (AUC), and effect and/or adverse effects, such as veno-occlusive disease (VOD), was reported. Exhaustion of glutathione (GSH) contributes to VOD and modulation of intracellular levels of GSH influences bulsulphan-induced toxicity in hepatocytes. Thus, increase of GSH might serve as prophylaxis against VOD. However, it should not… Expand
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References

SHOWING 1-10 OF 50 REFERENCES
Role of Oxidative Stress and Glutathione in Busulfan Toxicity in Cultured Murine Hepatocytes
  • L. DeLeve, Xiangdong Wang
  • Medicine, Biology
  • Pharmacology
  • 2000
Characterization of the mechanisms of busulfan resistance in a human glioblastoma multiforme xenograft
Pharmacokinetics of liposomal busulphan in man
...
1
2
3
4
5
...