The effect of mild hypothermia on plasma fentanyl concentration and biotransformation in juvenile pigs.

@article{Fritz2005TheEO,
  title={The effect of mild hypothermia on plasma fentanyl concentration and biotransformation in juvenile pigs.},
  author={Harald G. Fritz and Martin Holzmayr and Bernd Walter and K U M{\"o}ritz and Amelie Lupp and Reinhard Bauer},
  journal={Anesthesia and analgesia},
  year={2005},
  volume={100 4},
  pages={996-1002}
}
Therapeutic hypothermia may alter the required dosage of analgesics and sedatives, but no data are available on the effects of mild hypothermia on plasma fentanyl concentration during continuous, long-term administration. We therefore assessed in a porcine model the effect of prolonged hypothermia on plasma fentanyl concentration during 33 h of continuous fentanyl administration. Seven female piglets (weight: 11.8 +/- 1.1 kg) were anesthetized by IV fentanyl (15 microg . kg(-1) . h(-1)) and… CONTINUE READING

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