The effect of methylxanthines on morphine analgesia in mice and rats.

@article{Malec1988TheEO,
  title={The effect of methylxanthines on morphine analgesia in mice and rats.},
  author={Danuta Malec and Elzbieta Michalskă},
  journal={Polish journal of pharmacology and pharmacy},
  year={1988},
  volume={40 3},
  pages={223-32}
}
The influence of various doses of caffeine and theophylline on analgesic effect of morphine was tested in mice and rats in the hot plate and tail immersion tests. Caffeine in rats potentiated the morphine analgesia in both tests in a dose-dependent manner. In mice the caffeine-morphine interaction was biphasic: lower caffeine doses (10 and 25 mg/kg… CONTINUE READING