The effect of metabolic depression on proton leak rate in mitochondria from hibernating frogs.

@article{StPierre2000TheEO,
  title={The effect of metabolic depression on proton leak rate in mitochondria from hibernating frogs.},
  author={Julie St-Pierre and Martin D. Brand and Robert G. Boutilier Boutilier},
  journal={The Journal of experimental biology},
  year={2000},
  volume={203 Pt 9},
  pages={1469-76}
}
Futile cycling of protons across the mitochondrial inner membrane accounts for 20 % or more of the total standard metabolic rate of a rat. Approximately 15 % of this total is due to proton leakage inside the skeletal muscle alone. This study examined whether the rate of proton leak is down-regulated as a part of a coordinated response to energy conservation during metabolic depression in cold-submerged frogs. We compared the proton leak rate of skeletal muscle mitochondria isolated from frogs… CONTINUE READING

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