The effect of low dose continuous exposure to estradiol on the estrogen receptor (type I) and nuclear type II sites.

@article{Markaverich1984TheEO,
  title={The effect of low dose continuous exposure to estradiol on the estrogen receptor (type I) and nuclear type II sites.},
  author={Barry M. Markaverich and Robert S. Roberts and Mary Ann Alejandro and James H. Clark},
  journal={Endocrinology},
  year={1984},
  volume={114 3},
  pages={814-20}
}
These studies were done to evaluate the temporal relationships between cytoplasmic and nuclear estrogen receptors (type I sites), nuclear type II estrogen binding sites, and uterotropic response (true uterine growth; DNA content) after low dose estrogen administration to adult-ovariectomized rats by beeswax pellet implant. Administration of low dose (2.5 micrograms estradiol-17 beta/pellet) estrogen pellets resulted in a slight accumulation of nuclear type I sites (approximately 1700 sites per… CONTINUE READING

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