The effect of lipid and aqueous solubilities on flux of nicotinic acid esters from water through silicone membrane.


OBJECTIVE The maximum fluxes (J(M)) of nicotinic acid esters (NAE) across silicone membranes from water (J(MPAQ)) have been measured to determine how well they correlate with J(M) of NAE across human skin from water in vitro (J(MHAQ)) and in vivo (J(MHAQ1)) and with J(M) of NAE across hairless mouse skin from water (J(MMAQ)). MATERIALS AND METHODS The NAE… (More)
DOI: 10.3109/03639045.2012.694590

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