The effect of light and potassium depolarization on the release of endogenous amino acids from the isolated rat retina.

@article{Kennedy1978TheEO,
  title={The effect of light and potassium depolarization on the release of endogenous amino acids from the isolated rat retina.},
  author={ANTHONY J. Kennedy and Michael J. Neal},
  journal={Experimental eye research},
  year={1978},
  volume={26 1},
  pages={
          71-5
        }
}
The Synthesis of Neuroactive Amino Acids from Radioactive Glucose and Glutamine in the Rat Retina: Effects of Light Stimulation
TLDR
Results support the contention that glucose is the principal energy source for the retina, its entry into non‐amino acid derivatives being decreased on light stimulation.
Potassium‐Stimulated Release of Radiolabelled Taurine and Glycine from the Isolated Rat Retina
TLDR
Although high potassium concentrations increased the spontaneous emux of [3H]taurine from the superfused rat retina, this release was not evident until the depolarising stimulus was removed from the superficial medium, and the possible neuro‐transmitter roles of both amino acids in the rat retina were discussed.
Transmitter Release from the Retina
TLDR
A technique which is unique to the retina is the eye-cup preparation, in which the entire retina is exposed to superfusion with minimal disturbance.
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The release of endogenous amino acids from the rat visual cortex.
TLDR
The release of endogenous taurine, GABA, glycine, aspartate, glutamate, glutamine and alanine from the rat visual cortex was measured using a cortical cup technique and the proposed neurotransmitter roles of the physiologically active amino acids were proposed.
FACTORS AFFECTING THE SPONTANEOUS RELEASE OF [3H] γ‐AMINOBUTYRIC ACID FROM THE FROG RETINA IN VITRO
TLDR
The spontaneous efflux of [3H]GABA and its metabolites from the frog retina was multiphasic in the presence or absence of amino‐oxyacetic acid (AOAA), an inhibitor of GABA metabolism, and was not affected by light or dark adaptation.
The distribution of amino acids within the rat retina
TLDR
The amino-acid levels found in the present study are similar to those previously reported for the rat retina with the exception of taurine which was found to be approximately twice the level previously reported.
The uptake of 3H‐γ‐aminobutyric acid by the retina
TLDR
The retina was capable of achieving a large net uptake of GABA, indicating that the accumulation of 3H‐GABA by the tissue was not due only to an exchange process with the endogenous GABA pool, and may represent a possible mechanism for the inactivation of GABA if this amino acid is released at inhibitory synapses in the retina.