The effect of leptin on bone: an evolving concept of action.

@article{Cirmanov2008TheEO,
  title={The effect of leptin on bone: an evolving concept of action.},
  author={Veronika Cirmanov{\'a} and Mary Bayer and Luboslav St{\'a}rka and Kateřina Zaj{\'i}{\vc}kov{\'a}},
  journal={Physiological research},
  year={2008},
  volume={57 Suppl 1},
  pages={S143-51}
}
Leptin, a cytokine-like hormone secreted by adipocytes, is known to regulate food intake but has also emerged as a significant factor in the regulation of bone mass. In humans, states of energy deprivation with low serum leptin have been associated with low bone mass. In mice, leptin deficiency led to increased trabecular bone mass with overall decrease in cortical bone. Leptin regulates bone metabolism indirectly in the hypothalamus thereby activating the sympathetic nervous system (SNS). In… CONTINUE READING

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