The effect of laser profile, fluence, and spot size on sensitivity in orthogonal-injection matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

@article{Qiao2008TheEO,
  title={The effect of laser profile, fluence, and spot size on sensitivity in orthogonal-injection matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.},
  author={H. Qiao and Victor Spicer and Werner E Ens},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2008},
  volume={22 18},
  pages={2779-90}
}
The influence of incident laser parameters on sensitivity in matrix-assisted laser desorption/ionization (MALDI) has been investigated using orthogonal-injection time-of-flight (TOF) instruments. A qualitative comparison was first made between the beam profiles obtained with a N(2) laser and a Nd:YAG laser using 2-m long optical fibers. The N(2) laser gives better sensitivity, consistent with a more uniform fluence distribution and therefore better coverage of the N(2) laser profile. Most of… CONTINUE READING
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