The effect of lactose-conjugated silk biomaterials on the development of fibrogenic fibroblasts.

Abstract

Surface properties of implanted biomaterials can cause fibrotic tissue reactions by stimulating differentiation of host fibroblasts into contractile myofibroblasts. Silk fibroin (SF) protein has been used as biomaterial in pure and blended form. however, its effect on myofibroblast differentiation remains elusive. We here conjugated SF with lactose using… (More)
DOI: 10.1016/j.biomaterials.2008.08.033

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