The effect of ketoconazole on the jejunal permeability and CYP3A metabolism of (R/S)-verapamil in humans.

@article{Sandstrm1999TheEO,
  title={The effect of ketoconazole on the jejunal permeability and CYP3A metabolism of (R/S)-verapamil in humans.},
  author={Rikard Sandstr{\"o}m and Tina W. Knutson and Lars F. Knutson and Britt Jansson and Hans Lennernaes},
  journal={British journal of clinical pharmacology},
  year={1999},
  volume={48 2},
  pages={180-9}
}
AIMS The purpose of this human intestinal perfusion study was to investigate the effect of ketoconazole on the jejunal permeability and first-pass metabolism of (R)- and (S)-verapamil in humans. METHODS A regional single-pass perfusion of the jejunum was performed using a Loc-I-Gut(R) perfusion tube in six healthy volunteers. Each perfusion lasted for 200 min and was divided into two periods of 100 min each. The inlet concentration of (R/S)-verapamil was 120 mg l-1 in both periods, and… CONTINUE READING

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