The effect of kainic, quinolinic and beta-kainic acids on the release of endogenous amino acids from rat brain slices.

@article{Connick1986TheEO,
  title={The effect of kainic, quinolinic and beta-kainic acids on the release of endogenous amino acids from rat brain slices.},
  author={J H Connick and Trevor W Stone},
  journal={Biochemical pharmacology},
  year={1986},
  volume={35 20},
  pages={3631-5}
}
It has been suggested that the neurotoxic properties of quinolinic acid and kainic acid may, at least in part, involve an indirect action on nerve terminals containing glutamate. In the present study it is confirmed that kainate causes the release of endogenous glutamate from rat hippocampal slices, but that quinolinic acid does not share this activity. In addition beta-kainic acid was found to depress the potassium evoked release of endogenous glutamate at relatively high concentrations and… CONTINUE READING