The effect of itraconazole on the pharmacokinetics and pharmacodynamics of bromazepam in healthy volunteers

@article{Oda2003TheEO,
  title={The effect of itraconazole on the pharmacokinetics and pharmacodynamics of bromazepam in healthy volunteers},
  author={Manami Oda and Tsutomu Kotegawa and Kimiko Tsutsumi and Yasukiyo Ohtani and Keiji Kuwatani and Shigeyuki Nakano},
  journal={European Journal of Clinical Pharmacology},
  year={2003},
  volume={59},
  pages={615-619}
}
  • Manami Oda, Tsutomu Kotegawa, +3 authors Shigeyuki Nakano
  • Published 2003
  • Medicine
  • European Journal of Clinical Pharmacology
  • Rationale and objectiveBromazepam, an anti-anxiety agent, has been reported to be metabolized by cytochrome P450 (CYP). However, the enzyme responsible for the metabolism of bromazepam has yet to be determined. The purpose of this study was to examine whether the inhibition of CYP3A4 produced by itraconazole alters the pharmacokinetics and pharmacodynamics of bromazepam.MethodsEight healthy male volunteers participated in this randomized double-blind crossover study. The subjects received a 6… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 23 REFERENCES

    Drug interactions with fluconazole.

    VIEW 1 EXCERPT

    Clinical pharmacokinetics of lorazepam: a review.

    VIEW 1 EXCERPT