The effect of isoflurane on excitatory synaptic transmission in the rat hippocampus.

@article{BergJohnsen1992TheEO,
  title={The effect of isoflurane on excitatory synaptic transmission in the rat hippocampus.},
  author={Jon Berg-Johnsen and Iver Arne Langmoen},
  journal={Acta anaesthesiologica Scandinavica},
  year={1992},
  volume={36 4},
  pages={350-5}
}
The purpose of this investigation was to study the effect of isoflurane on excitatory synaptic transmission. Rat hippocampal slices maintained in vitro were used as a model. Isoflurane caused a dose-dependent reduction of the excitatory postsynaptic potential (EPSP); 1.5% isoflurane reduced the EPSP by 35 +/- 9% (mean +/- s.d.) and 3% by 57 +/- 11%. Neither spontaneous nor potassium-stimulated efflux of the glutamate analogue D-(3H)aspartate was changed, but the content of D-(3H)aspartate in… CONTINUE READING

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