The effect of irradiation on expression of HLA class I antigens in human brain tumors in culture.

  title={The effect of irradiation on expression of HLA class I antigens in human brain tumors in culture.},
  author={Baruch Klein and David Lov{\'e}n and Hedwig Lurie and Erica Rakowsky and Abraham Nyska and Israel Levin and Tirza Klein},
  journal={Journal of neurosurgery},
  volume={80 6},
The immunosuppressive effects of irradiation are well known; however, under certain circumstances irradiation also augments the local immune response by as yet undefined mechanisms. Because of the importance of HLA class I antigen in immune regulation and the fact that killing of tumor cells by cytotoxic T cells is HLA antigen-restricted, the authors studied HLA class I antigen expression in eight glioblastomas multiforme, four meningiomas, and four medulloblastomas. Twenty fragments of each… 

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  • B. KleinT. Klein H. Lurie
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    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • 1991
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