The effect of iron overload on in vitro HIV-1 infection.

@article{Traor2004TheEO,
  title={The effect of iron overload on in vitro HIV-1 infection.},
  author={Hafsatou Ndama Traor{\'e} and Debra Meyer},
  journal={Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology},
  year={2004},
  volume={31 Suppl 1},
  pages={
          S92-8
        }
}
BACKGROUND It has been shown that Fe is required by HIV-infected cells for production of viral particles. Excess iron in the cell is detrimental to the host but beneficial to the pathogen. OBJECTIVES Here, we investigated the effect of excess Fe (overload) and chelation of the metal on in vitro HIV infection by assessing host cell responses (viability/death, stress protein expression and cytokine production) as well as virus replication (core protein content and enzyme activity). RESULTS… CONTINUE READING

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