The effect of iodination of particular tyrosine residues on the hormonal activity of insulin.

@article{Garratt1972TheEO,
  title={The effect of iodination of particular tyrosine residues on the hormonal activity of insulin.},
  author={C J. Garratt and Dave Harrison and Mike Wicks},
  journal={The Biochemical journal},
  year={1972},
  volume={126 1},
  pages={123-31}
}
Insulin dissolved in aqueous or methanolic buffer was iodinated to give preparations containing an average of between one and five iodine atoms per insulin monomer. The resultant preparations were fragmented in various ways and the ratio of tyrosine to monoiodotyrosine and di-iodotyrosine was determined in each fragment. This has allowed the distribution of… CONTINUE READING