The effect of introduction of some drugs into the cerebral ventricles on the electrical activity of the brain of cats.

@article{Cooke1954TheEO,
  title={The effect of introduction of some drugs into the cerebral ventricles on the electrical activity of the brain of cats.},
  author={Pauline M. Cooke and STEPHEN L. Sherwood},
  journal={Electroencephalography and clinical neurophysiology},
  year={1954},
  volume={6 3},
  pages={
          425-31
        }
}
14 Citations

Die neurophysiologischen Grundlagen der Wirkung von Tranquillisatoren

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A comparison of pediatria and blood sugar levels in Napoli and London between 1950 and 1950 and the period of time up to and including 1953 shows clear trends in favour of the latter.

Action of acetylcholine and carbachol when injected into the cerebral ventricles

  • E. Rutman
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    Bulletin of Experimental Biology and Medicine
  • 2004
TLDR
Acetylcholine and carbocholine administered into the lateral ventricle of the rabbit brain caused a distinct, stable picture of activation of the EEG, excitation and in a number of cases exophthalmos and bradycardia.

Electroencephalographic Correlates of Nerve Agent Poisoning

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Results from this early EEG study are consistent with current understanding of the effects of antiChE drugs on the CNS and the description of these effects is generally consistent with the modern-day definition of EEG desynchronization or arousal.

Central nervous respiratory depressants--control-systems approach to respiratory depression.

  • H. Borison
  • Medicine
    Pharmacology & therapeutics. Part B: General & systematic pharmacology
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Newborn responses to nonsignal auditory stimuli: I. Electroencephalographic desynchronization.

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Increased EEG desynchronization to stimulation was found but the response appears to be a complex function of the type of stimulus, recording location, stimulus repetition, and the prior experience variable.

EFFECTS OF PSYCHOTROPIC DRUGS ON BEHAVIOR AND EEG, FOLLOWING DIRECT ADMINISTATION TO DOG'S BRAIN

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Two kinds of psychotropic drugs, chlorpromazine and imipramine, were examined in forty‐one dogs by means of the conditioned avoidance response and the electrocorticogram, with neither anaesthesia nor restraint.

Actions at the Central Nervous System

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The only complete review of the pharmacology of anti-ChE agents presently available is the excellent one by Holmstedt (1959), which, however, does not include cholinesterase (ChE) inhibitors other than organophosphorus compounds.

References

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Experiments on cats in which these symptoms have been produced by lesions at the base of the brain in the region of transition between the forebrain and the midbrain have shown that there is no binding relationship between the depth of the somnolence and the ease with which the animals can be made to assume and maintain unusual postures.

BULBOCAPNINE: EFFECT ON ANIMALS WITH LESIONS OF THE CENTRAL NERVOUS SYSTEM

The typical picture of catalepsy as produced by moderate doses of bulbocapnine is now widely known; for the present it is sufficient to recall that it is chiefly characterized by immobility, loss of

Effects of Lesions of the Periaqueductal Gray Matter in the Cat∗

TLDR
Developing an electrode which could be inserted by an opening in the occipitoatlantoid ligament through the fourth ventricle into the aqueduct and made electrolytic lesions confined to the periaqueductal gray matter of the cat, which served as controls for the production of numerous lesions in all parts of the midbrain.

Effects of chronic lesions in central cephalic brain stem of monkeys.

TLDR
The evidence suggests that this activating system is of particular importance in initiating and maintaining an alert or attentive state in the animal, rendering it capable of reacting adaptively to stimuli in a way impossible in sleep.

Injections of drugs into the lateral ventricle of the cat

TLDR
The method formerly used for intraventricular injections in unanaesthetized animals has the following drawbacks: the animals are physically restrained; fear, pain and other defence reactions may overshadow or modify the drug effect; and there must always remain a certain doubt whether injury of the brain substance has occurred and is responsible for the observed effects.

An ascending reticular activating system in the brain stem.

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  • Psychology, Biology
    Harvey lectures
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TLDR
The waking state has generally been thought to depend in an important fashion upon the arousing influence at the cerebral cortex of afferent messages initiated by sensory stimulation.

Acetylcholine synthesis in different regions of the central nervous system

TLDR
It has been shown that this enzyme can be extracted from acetone-dried tissue and that such extracts form large amounts of acetylcholine in the presence of KCI, MgCl2, choline, cysteine, citrate and adenosine-triphosphate.

Ascending conduction in reticular activating system, with special reference to the diencephalon.

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The results indicate that the ventromedial part of the thalamus is most critically involved in transmission of the reticular activating influence, with the rest of theThalamus (including the diffuse thalamic projection system) playing a subsidiary role.

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