The effect of intravenous lidocaine on experimental brain edema and neural activities.

@article{Nagao1988TheEO,
  title={The effect of intravenous lidocaine on experimental brain edema and neural activities.},
  author={Shoji Nagao and T. Murota and Fumiyuki Momma and Hideyuki Kuyama and Akira Nishimoto},
  journal={The Journal of trauma},
  year={1988},
  volume={28 12},
  pages={1650-5}
}
A series of experiments was conducted to clarify the effect of intravenous administration of lidocaine on brain water content, local cerebral blood flow (lCBF), and neural recovery in brain injury induced by exposure of the cat's cerebral surface to the air. The injury produced ischemia and edema in the cortex and white matter without direct damage of the cortex. Lidocaine (3.0 mg/kg) was given intravenously for 30 minutes immediately after air exposure and thereafter at the rate of 2 mg/kg… CONTINUE READING