The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: a phase II randomised controlled trial

@inproceedings{Singh2013TheEO,
  title={The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: a phase II randomised controlled trial},
  author={Navneet Singh and Stephen John Hopkins and Sharon Hulme and James P Galea and Margaret E. Hoadley and Andy Vail and Peter J Hutchinson and Samantha Grainger and Nancy J. Rothwell and Andrew Thomas King and Pippa Tyrrell},
  booktitle={Journal of Neuroinflammation},
  year={2013}
}
Interleukin-1 (IL-1) is a key mediator of ischaemic brain injury induced by stroke and subarachnoid haemorrhage (SAH). IL-1 receptor antagonist (IL-1Ra) limits brain injury in experimental stroke and reduces plasma inflammatory mediators associated with poor outcome in ischaemic stroke patients. Intravenous (IV) IL-1Ra crosses the blood–brain barrier (BBB) in patients with SAH, to achieve cerebrospinal fluid (CSF) concentrations that are neuroprotective in rats. A small phase II, double-blind… CONTINUE READING
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