The effect of intrauterine and oral levonorgestrel administration on serum concentrations of sex hormone-binding globulin, insulin and insulin-like growth factor binding protein-1.

@article{Pakarinen1999TheEO,
  title={The effect of intrauterine and oral levonorgestrel administration on serum concentrations of sex hormone-binding globulin, insulin and insulin-like growth factor binding protein-1.},
  author={P{\"a}ivi I Pakarinen and Pekka L{\"a}hteenm{\"a}ki and E. M. Rutanen},
  journal={Acta obstetricia et gynecologica Scandinavica},
  year={1999},
  volume={78 5},
  pages={423-8}
}
BACKGROUND The concentrations of sex hormone-binding globulin (SHBG) have been shown to decrease during the use of levonorgestrel (LNG)-containing contraception. This decrease has been thought to be due to the androgenic action of LNG. In endogenously hyperandrogenic women, particularly in those with increased body weight, serum SHBG correlates with circulating insulin-like growth factor binding protein-1 (IGFBP-1) concentration, and both are inversely related to insulin. LNG-containing… CONTINUE READING