The effect of intrastriatal injection of liposome-entrapped tyrosinase on the dopamine levels in the rat brain.

@article{Amicarelli1999TheEO,
  title={The effect of intrastriatal injection of liposome-entrapped tyrosinase on the dopamine levels in the rat brain.},
  author={Fernanda Amicarelli and Antonella Gasbarri and L Masciocco and Assunta Pompili and Claudio Pacitti and Giuseppe Carlucci and Giuseppe Palumbo and Michele Miranda},
  journal={Cellular and molecular biology},
  year={1999},
  volume={45 7},
  pages={1093-7}
}
Parkinson's disease is a neurodegenerative disorder which is mainly characterized by degeneration of the dopaminergic cells in the nigro-striatal system. Due to a lowered L-tyrosine 3-monooxygenase activity, L-tyrosine is not sufficiently transformed to L-DOPA. To date the most common therapy is the administration of the dopamine precursor L-DOPA, with severe collateral effects. Therefore, the substitution of the lacking tyrosine hydroxylase with tyrosinase might be a novel therapeutical… CONTINUE READING
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