The effect of intramuscular progesterone on the rate of cervical shortening.

@article{Pessel2013TheEO,
  title={The effect of intramuscular progesterone on the rate of cervical shortening.},
  author={C. Pessel and Saila S. Moni and N. Zork and S. Brubaker and J. Vink and K. Fuchs and C. Nhan‐Chang and C. Ananth and C. Gyamfi‐Bannerman},
  journal={American journal of obstetrics and gynecology},
  year={2013},
  volume={209 3},
  pages={
          269.e1-7
        }
}
OBJECTIVE The purpose of the study was to evaluate whether 17-alpha-hydroxyprogesterone caproate (17-OHPC) exposure is associated with the rate of cervical shortening. STUDY DESIGN Women with a history of spontaneous preterm delivery (PTD) at <37 weeks' gestation who had serial cervical length measurements (2009-2012) were identified. 17-OHPC administration and outcome data were collected. We excluded patients with multiple gestations, indicated PTDs, major fetal anomalies, cerclage, and… Expand
The effect of prenatal vaginal progesterone on cervical length in nonselected twin pregnancies
TLDR
Cervical shortening in asymptomatic nonselected twin pregnancies occurred at a similar rate, regardless of vaginal progesterone treatment, according to gestational age at birth. Expand
Effectiveness of dydrogesterone, 17-OH progesterone and micronized progesterone in prevention of preterm birth in women with a short cervix
  • O. Pustotina
  • Medicine
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2018
TLDR
Combination management strategy including VP significantly benefits pregnancy outcomes in women with a short cervix compared with cerclage, and significantly decreased the rate of preterm birth and low birth weight. Expand
17 alpha-hydroxyprogesterone caproate does not prolong pregnancy or reduce the rate of preterm birth in women at high risk for preterm delivery and a short cervix: a randomized controlled trial.
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17OHP-C did not prolong pregnancy in women with singleton gestations, a sonographic short cervix, and other risk factors of preterm delivery (prior history, uterine malformations, cervical surgery, or prenatal DES exposure). Expand
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Preterm labor is defined as birth before 37 week of pregnancy. Despite of progressive improvement in gynecological care, the prevalence of preterm labor is growing. The aim of this study was toExpand
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This review will examine the plausibility of 17-OHPC in preventing preterm birth and the investigation of its clinical efficacy and highlight factors to explain variations in clinical trial outcomes and outline the trajectory needed for future investigations. Expand
Prevention of preterm birth with vaginal progesterone or 17-alpha-hydroxyprogesterone caproate: a critical examination of efficacy and safety.
TLDR
Evidence from a single large comparative efficacy trial suggests that vaginal natural progesterone is superior to 17-hydroxyprogesterone caproate as a prophylactic treatment in women with a history of mid-trimester preterm birth, and the synthetic drug is contraindicated in this population. Expand
Vaginal progesterone, but not 17α-hydroxyprogesterone caproate, has antiinflammatory effects at the murine maternal-fetal interface.
TLDR
Vaginal progesterone, but not 17OHP-C, has local antiinflammatory effects at the maternal-fetal interface and the cervix and protects against endotoxin-induced PTB. Expand
Pessary use in pregnant women with short cervix.
TLDR
Pessary application was associated with a prolongation of pregnancy lasting between 28 and 98 days and the gestational age at the time of delivery was between the 33rd and 39th weeks. Expand
Effect of cervical cerclage on rate of cervical shortening
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  • 2015
TLDR
Evaluated whether cerclage affects the rate of cervical shortening taking into account exposure to 17‐hydroxyprogesterone and vaginal progesterone in a high‐risk patient population. Expand
Pharmacy Compounding Quality Control and Pharmaceutical Development Strategies for Seventeen alpha Hydroxyprogesterone Caproate in Prevention of Preterm Delivery
TLDR
Surprisingly, the surveyed physicians reported that there was about half of eligible patients seen in their practice but not prescribed 17-OHPC, and the financial and logistical barriers carried the most weight in the decision not to prescribe FDAapproved 17- OHPC to an eligible patient. Expand
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