• Corpus ID: 53375487

The effect of intralesional meglumine antimoniate (glucantime) versus a combination of 50% topical trichloroacetic acid and local heat therapyby non-ablative radiofrequency on cutaneous leishmaniasis lesions

  title={The effect of intralesional meglumine antimoniate (glucantime) versus a combination of 50\% topical trichloroacetic acid and local heat therapyby non-ablative radiofrequency on cutaneous leishmaniasis lesions},
  author={Mohammad Ali Nilforoushzadeh and Farahnaz Fatemi Naeeni and Narges Sattar and Elaheh Haftbaradaran and Fariba Jaffary and Gholamreza Askari},
  journal={Journal of Research in Medical Sciences},
Mohammad Ali Nilforoushzadeh, Farahnaz Fatemi Naeeni, Narges Sattar, Elaheh Haftbaradaran, Fariba Jaffary, Gholamreza Askari 1 Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran And Skin Disease and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 2 Skin Disease and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 3 Skin Disease and Leishmaniasis Research Center And Department of… 

Tables from this paper

A Comparison between the Effects of Glucantime, Topical Trichloroacetic Acid 50% plus Glucantime, and Fractional Carbon Dioxide Laser plus Glucantime on Cutaneous Leishmaniasis Lesions
Compared to glucantimes alone, the combination of intralesional glucantime and TCA 50% or fractional CO2 laser had significantly higher and faster cure rate in patients with cutaneous leishmaniasis.
Treatment of Glucantim TM-Resistant Cutaneous Leishmaniasis Using Combination Therapy of Allopurinol and Trichloroacetic Acid ( TCA ) 50 % ; Report of Three Cases
The use of combination therapy of allopurinol and TCA 50% could be used as one of the alternative treatments in GlucantimTMresistant cutaneous leishmaniasis.
Efficacy of pentavalent antimoniate intralesional infiltration therapy for cutaneous leishmaniasis: A systematic review
It was determined that patients submitted to IL-Sbv treatments longer than 14 days had higher cure rates and an indirect comparison shows that the antimony infiltration efficacy rate is similar to that reported for antimony systemic use.
Eligibility criteria and outcome measures adopted in clinical trials of treatments of cutaneous leishmaniasis: systematic literature review covering the period 1991–2015
To document the sources of heterogeneity in outcomes and shortcomings in trial designs reported by previous systematic reviews, a meta-analysis of 120 trials over a 25-year period found that eight out of 10 trials had at least some heterogeneity in their experimental design.
Sistematización de Estudios Clínicos Sobre la Eficacia de Tratamientos para la Leishmaniasis Cutánea 1980-2015
Esta investigacion evidencia el elevado interes en the investigacion of medicamentos contra the enfermedad, principalmente en los paises endemicos y the baja calidad metodologica of the mayoria of estudios incluidos.


The efficacy of treatment with intralesional meglumine antimoniate alone, compared with that of cryotherapy combined with the meglumine antimoniate or intralesional sodium stibogluconate, in the treatment of cutaneous leishmaniasis
The main aim of the present, Iranian study was to see if the combination of cryotherapy and intralesional injections with meglumine antimoniate (C + MA) would be more effective than the injections given alone (MA) or the combinationof cryotherapy plus intralsional sodium stibogluconate (C - SS).
The efficacy of 5% trichloroacetic acid cream in the treatment of cutaneous leishmaniasis lesions
Cutaneous Leishmaniasis is an endemic disease in Iran and 5% TCA cream is a potential alternative for intralesional glucantime in the treatment of CL, with promising aspects in reducing the scar size and the low cost.
Treatment of cutaneous leishmaniasis with either topical paromomycin or intralesional meglumine antimoniate
It is indicated that intralesional meglumine antimoniate is superior to topical paromomycin in the treatment of cutaneous leishmaniasis.
Efficacy of local heat therapy by radiofrequency in the treatment of cutaneous leishmaniasis, compared with intralesional injection of meglumine antimoniate
This data indicates that the number of cases of cutaneous leishmaniasis in sub-Saharan Africa is increasing and the need for further research into the causes and treatment of this disease is increasing.
Treatment of cutaneous leishmaniasis with ketoconazole cream
The low response rate in patients receiving ketoconazole cream indicates that it cannot be used as the single agent in the treatment of CL patients.
A Randomized Controlled Trial of Local Heat Therapy Versus Intravenous Sodium Stibogluconate for the Treatment of Cutaneous Leishmania major Infection
Skin lesions due to L. major treated with heat delivered by the ThermoMed device healed at a similar rate and with less associated systemic toxicity than lesions treated with intravenous SSG.
Efficacy of cryotherapy versus intralesional meglumine antimoniate (glucantime) for treatment of cutaneous leishmaniasis in children.
Cryotherapy should be recommended as an appropriate alternative treatment for leishmaniasis in children because of its simplicity, lower cost, low rate of serious complications, and greater tolerability.
Human leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last 10 years.
  • J. Berman
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 1997
The current interest in leishmaniasis stems from the importance of this disease with respect to travel medicine, veterans of Operation Desert Storm, humanitarian concerns, and infection with human
Effect of combination therapy with systemic glucantime and pentoxifylline in the treatment of cutaneous leishmaniasis
First line treatment for cutaneous leishmaniasis is antimonial compounds; however, owing to the intermittent failure of this treatment and its significant side‐effects alternative therapeutic measures have been advocated.
Cutaneous leishmaniasis: an overview.
Sodium stibogluconate 20mg/kg/day i.v. for 20 days is the appropriate first line treatment in simple cutaneous leishmaniasis, which appears safe and should be followed up for 6 months.