The effect of intra-articular colchicine on the knee joint of the rat.


The effect of intra-articular injections of colchicine on the normal joint of the rat was investigated. Colchicine in varying doses was injected into the knee, while the contralateral knee was used as a control. Colchicine mainly affected articular cartilage, causing degenerative changes that appeared to be dose-dependent. It is assumed that colchicine… (More)


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