The effect of interstitial pressure on tumor growth: coupling with the blood and lymphatic vascular systems.

@article{Wu2013TheEO,
  title={The effect of interstitial pressure on tumor growth: coupling with the blood and lymphatic vascular systems.},
  author={Min Wu and Hermann B. Frieboes and Steven R. McDougall and Mark A. J. Chaplain and Vittorio Cristini and John S. Lowengrub},
  journal={Journal of theoretical biology},
  year={2013},
  volume={320},
  pages={131-51}
}
The flow of interstitial fluid and the associated interstitial fluid pressure (IFP) in solid tumors and surrounding host tissues have been identified as critical elements in cancer growth and vascularization. Both experimental and theoretical studies have shown that tumors may present elevated IFP, which can be a formidable physical barrier for delivery of cell nutrients and small molecules into the tumor. Elevated IFP may also exacerbate gradients of biochemical signals such as angiogenic… CONTINUE READING