The effect of interleukin-6 on pituitary hormone release in vivo and in vitro.

@article{Lyson1991TheEO,
  title={The effect of interleukin-6 on pituitary hormone release in vivo and in vitro.},
  author={Krzysztof Lyson and S. M. Mccann},
  journal={Neuroendocrinology},
  year={1991},
  volume={54 3},
  pages={
          262-6
        }
}
Intravenously administered interleukin-6 (IL-6), a monokine produced by activated monocytes and folliculostellate cells of the pituitary gland, has been recently reported to elevate plasma ACTH level and to stimulate PRL, GH and LH release from cultured pituitary cells. To determine the site(s) of action of IL-6 in the control of pituitary hormone release, we injected human recombinant IL-6 into the third brain ventricle (3V) of freely moving, conscious male rats. Both 0.05 and 0.25 pmol doses… CONTINUE READING
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